1. What is the Cockroft And Gault Equation?

The Cockroft-Gault equation estimates creatinine clearance (CrCl) from serum creatinine, age, weight, and sex. It is commonly used to adjust drug dosages in patients with renal impairment.

2. How Does the Calculator Work?

The calculator uses the Cockroft-Gault equation:

Where:

• \( age \) — Age in years
• \( weight \) — Body weight in kg
• \( SCr \) — Serum creatinine (mg/dL)
• 0.85 — Female multiplier

Explanation: The equation estimates creatinine clearance based on age-related decline in kidney function, body size, and gender differences in muscle mass.

3. Importance of CrCl Calculation

Details: Creatinine clearance is important for drug dosing adjustments in patients with kidney impairment and for assessing renal function when more precise measurements aren't available.

4. Using the Calculator

Tips: Enter age in years, weight in kg, serum creatinine in mg/dL, and select gender. All values must be valid (age 1-120, weight > 0, SCr > 0).

5. Frequently Asked Questions (FAQ)

Q1: Why use Cockroft-Gault instead of eGFR?
A: Cockroft-Gault estimates creatinine clearance (mL/min) rather than GFR, and is still widely used for drug dosing calculations.

Q2: What are normal CrCl values?
A: Normal is approximately 95-125 mL/min for young men and 85-115 mL/min for young women, decreasing with age.

Q3: Should actual or ideal body weight be used?
A: For obese patients, consider using ideal body weight or adjusted body weight to avoid overestimation of renal function.

Q4: Are there limitations to this equation?
A: Less accurate in extremes of age/weight, amputees, patients with unstable creatinine, and those with very low or high muscle mass.

Q5: When is measured creatinine clearance preferred?
A: For precise drug dosing in critical situations or when the equation is likely to be inaccurate (e.g., severe obesity, malnutrition).