1. What is the Cockcroft-Gault Equation?

The Cockcroft-Gault equation estimates creatinine clearance (CrCl) which correlates with glomerular filtration rate (GFR). It's commonly used for drug dosing adjustments in patients with renal impairment.

2. How Does the Calculator Work?

The calculator uses the Cockcroft-Gault equation:

Where:

• \( age \) — Age in years
• \( weight \) — Body weight in kg
• \( Scr \) — Serum creatinine (mg/dL)
• 0.85 — Female multiplier

Explanation: The equation estimates creatinine clearance based on age, weight, gender, and serum creatinine level.

3. Importance of CrCl Calculation

Details: Creatinine clearance is important for adjusting medication dosages in patients with kidney impairment and assessing renal function.

4. Using the Calculator

Tips: Enter age in years, weight in kg, serum creatinine in mg/dL, and select gender. All values must be valid (age 1-120, weight > 0, Scr > 0).

5. Frequently Asked Questions (FAQ)

Q1: What's the difference between CrCl and eGFR?
A: CrCl estimates creatinine clearance while eGFR estimates glomerular filtration rate. They correlate but aren't identical.

Q2: What are normal CrCl values?
A: Normal is about 95-125 mL/min for men and 85-115 mL/min for women, decreasing with age.

Q3: When should I use ideal body weight?
A: For obese patients (BMI >30), consider using ideal body weight rather than actual weight.

Q4: Are there limitations to this equation?
A: Less accurate in elderly, very low/high muscle mass, amputees, and those with rapidly changing kidney function.

Q5: Should this be used for drug dosing?
A: Many drug dosing guidelines still use Cockcroft-Gault, though some are transitioning to CKD-EPI.